Grapes May Protect Against Metabolic Syndrome-Related Organ Damage
Grapes may help to limit the organ damage typically associated with metabolic syndrome, according to new research presented recently at the Experimental Biology conference in Boston.
Polyphenols — compounds that are found in many fruits and vegetables, including grapes, are theorized to be responsible for these health effects. Possibly in the same way that grapes reduce the heart failure that usually accompanies hypertension — via the activation of antioxidant producing genes.
The new research investigated “the effects of a high fat, American-style diet both with added grapes and without grapes (the control diet) on the heart, liver, kidneys, and fat tissue in obesity-prone rats. The grapes — a blend of red, green and black varieties — were provided as a freeze-dried grape powder and integrated into the animals’ diets for 90 days.”
What the researchers found was that “three months of a grape-enriched diet significantly reduced inflammatory markers throughout the body, but most significantly in the liver and in abdominal fat tissue. Consuming grapes also reduced liver, kidney and abdominal fat weight, compared with those consuming the control diet. Additionally, grape intake increased markers of antioxidant defense, particularly in the liver and kidneys.”
“Metabolic syndrome is a cluster of conditions that occur together — increased blood pressure, a high blood sugar level, excess body fat around the waist or low HDL (the good cholesterol) and increased blood triglycerides — significantly increasing the risk for heart disease, stroke and Type 2 diabetes. Intake of fruits and vegetables is thought to reduce these risks, and grapes have shown benefits in multiple studies. Metabolic syndrome is a major public health concern, and is on the rise in the U.S.”
“Our study suggests that a grape-enriched diet may play a critical role in protecting against metabolic syndrome and the toll it takes on the body and its organs,” said Seymour, as quoted by the University of Michigan Health System. “Both inflammation and oxidative stress play a role in cardiovascular disease progression and organ dysfunction in Type 2 diabetes. Grape intake impacted both of these components in several tissues which is a very promising finding.”